Abstract: Center-of-Mass (CoM) correction is a kind of systematic bias which must be corrected in precise orbit determination (POD) using satellite laser ranging (SLR) data. Numerical simulation and theoretical analysis have demonstrated the dependence of CoM corrections on system operating modes of SLR stations due to satellite signature effect, i.e. different CoM corrections should be applied on SLR data from different stations. For the first time, we analyze the influence on POD exerted by such dependence. Statistics over long-time series showed after adopting system-dependent CoM correction, the short-arc orbit determination precision has indeed undergone general improvement comparing to the situation of traditional global uniform CoM correction. The mean precision improvement is approximately 0.4 mm for Lageos-1/2 and 0.6 mm for Etalon-1/2. As the current requirements on SLR data processing for relevant applications have achieved sub-centimeter even towards millimeter level, it is necessary to take in the effect of system-dependent CoM correction.